Trypanosoma

Cryo Electron Microscopy


Cryo-electron microscopy (Cryo-EM)
is a technique which received the Nobel Prize in 2017 and revolutionised the process of studying proteins. One of the Cryo-EM methods, called cryo electron tomography, goes one step further. This method includes freezing the cells or tissues at the high speed, transferring them to the EM and then examining at approximately -190°C. After acquiring the series of two-dimensional images, they are then converted into 3D model. While being extremely powerful for studying protein interactions in situ, this method is very laborious and is therefore currently only available to a few laboratories in the world.

Delmic is currently working on a project which is aimed to simplify the complex workflows involved in cryo electron tomography. As a part of a consortium, members of which have years of experience in the fields of cryogenic technologies, vacuum systems and correlative light and electron microscopy, we are working on developing improved solution for the automated sample preparation, contamination-free transfer of samples into the microscope and the archiving of frozen specimens. The new automated workflow CETFlow (Cryogenic Electron Tomography WorkFlow) is aimed for a larger group of users and will unlock cryo electron tomography to a far wider range of users.

Whether you are already doing cryo-ET, or are looking for ways to do it faster and better, contact us directly at info@delmic.com or by leaving your details below to know more.

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Cryo Consortium

 

Delmic Cryo EM consortium


Max Planck Institute (MPI) of Molecular Physiology in Dortmund

The group of Prof. Dr. Stefan Raunser, director of The MPI in Dortmund, focuses on the molecular understanding of fundamental cellular processes and has a lot of expertise in the field of Cryo-EM.

Demcon kryoz

Demcon kryoz is part of the Demcon holding, a Dutch mechatronic engineering company. Demcon kryoz specializes in developing and delivering unique cryogenic solutions and thermal solutions for various applications.

CryoVAC

CryoVAC low temperature technologies inc. is a medium-sized company from Troisdorf, which has a long tradition in the production of cryogenic and vacuum systems.

University of Twente

The group of Prof. Dr. Srinivas Vanapalli at the University of Twente investigates new cooling systems.

Eurostars

Eurostars is a joint funding programme of EUREKA and the European Commission, which will be continued under the name Eurostars 2 under the Horizon 2020. Eurostars supports international innovative projects led by research and development-performing small-and medium-sized enterprises (R&D-performing SMEs). Eurostars works according to the same principle as the EUREKA initiative: Eurostars projects are open to technology and serve civil purposes. Eurostars aims to bring increased value to the economy, higher growth and more job opportunities.

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This project has received funding from the Eurostars-2 joint programme with co-funding from the European Union Horizon 2020 research and innovation programme.