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Reduce Ice Contamination. Increase Lamella Yield.

High-resolution structural determination is a numbers game. Reaching sub-nanometer resolution requires hundreds, if not thousands, of high-quality tomograms. The Clean Station makes this high-throughput requirement a reality. Its ultra-dry environment (< 50 ppm) ensures ice-free sample handling and transfer, maximizing your yield.

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Advantages of the Clean Station

list-arrow Protect vitrified samples from ice contamination during handling and transfer

list-arrow Enable a reproducible, easy-to-learn lamella handling workflow

list-arrow Dedicate expensive cryo-FIB time to lamella milling, not sample cleaning

list-arrow Eliminate tool-drying downtime and increase system uptime

Improve Cryo-ET Sample Preparation Efficiency with an Intuitive, Ice-Free Workflow

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An ice-free environment for uninterrupted productivity

By maintaining ultra-low humidity (< 50 ppm), the Clean Station eliminates atmospheric ice contamination. This allows you to focus on precise specimen handling without the stress of a time-critical workflow. With frost-free tools and dewars, you can remove repetitive drying cycles from your routine and maintain constant operational readiness.

 

Exchangeable gloves for maximum tactile control

This system is designed for full compatibility with standard thin nitrile gloves. This ensures you maintain the dexterity and "feel" required to handle even your most delicate samples with absolute confidence.

Integrated modules for a streamlined cryo-workflow

From the built-in liquid nitrogen tap to specialized preparation modules, every tool is designed to support clipping, shuttle, cassette, and capsule loading. This integrated approach ensures that every critical step of your workflow is performed under stable, optimal cryogenic conditions for maximum sample integrity.

Contamination-free transfer

Our load lock is fully compatible with existing transfer sticks, providing a secure and contamination-free environment for moving samples from one instrument to another. 

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Protect precious samples

Traditional cryo-ET workflows often hide failures until the final imaging stage, where hours of intensive FIB milling are rendered useless by ice contamination obscuring your precisely targeted regions of interest (ROI). For non-renewable specimens like human biopsies, this represents the permanent loss of unique biological data. The Clean Station provides an ultra-dry preparation environment that prevents ice contamination and protects irreplaceable samples and regions of interest.

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Save cryo-FIB time

In the SOLIST workflow, lamellae are deposited onto receiver grids and any surface contamination can render a grid square completely unusable for deposition. This forces researchers to divert valuable cryo-FIB time toward manually cleaning each square, creating a significant bottleneck in experimental throughput. By utilising the Clean Station for clipping and sample loading, all grid squares remain pristine, ensuring your FIB is used for lamella milling, not cleaning. 

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Explore your options

Reach out to our team of specialists to find out how the CERES Clean Station can make your sample preparation process more comfortable and more effective.

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Partners

Innovating with experts in the field

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“In the TEM, contamination used to appear during tilt series acquisition, masking exposure areas and disrupting tracking focus. With the Clean Station, the entire surface of the lamellae is available for imaging, eliminating these issues.”

Jean Daraspe Université de Lausanne (UNIL)

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“With these powerful tools, we were able to streamline the cryo-FIB/SEM automation process. Since there is no contamination visible, we were able to polish our lamellae automatically to a thickness of less than 150 nm.”

Dr. Sebastian Tacke Max Planck Institute of Molecular Physiology

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Looking forward together

Company Logo - Strubi
Company Logo - Munster University
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Company Logo - MPI Molecular Physiology

Insights

2023_CERES CS VL Front_Text and Image

Brochure System specifications

Contamination free cryo-EM sample preparation

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Webinar Sample protection

Minimizing sample contamination in cryo-ET with Delmic's CERES Ice Defence System

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Blog Cryo-ET

Preventing ice contamination in the cryo-ET workflow

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Interested to find a solution for your research?

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