Study cellular dynamics and the ultrastructure of infected cells simultaneously by combining the power of light and electron microscopy. With our CLEM solutions you can detect viruses and study their unique ultrastructure using one system.
In the field of virology, Giant Viruses have received special interest because they can infect a broader host range and because they can enter cells through phagocytosis that does not require specific viral-host interactions. Fluorescence microscopy using fluorescent markers provides analytical, quantitative and three-dimensional data. Because the diameter of Giant Viruses is larger than the optical resolution limit, they are readily visible in bright-field (BF)
transmitted light or Fluorescence microscopy. However, Giant Viruses are rarely observed by LM due to the lack of access to ultrastructure since only Electron Microscopy can provide structural information with sufficiently high resolution. Integrated Correlative Light and Electron microscopy (CLEM) is a powerful tool to bridge the gap between both methods.
The combination of light and electron microscopy enables you to zoom in and out seamlessly on the same sample and observe the cellular dynamics and the ultrastructure of any object of interest. The SECOM platform is a fast, accurate and easy-to-use system that enables one to do correlative microscopy extremely fast with the highest optical quality and overlay accuracy. The SECOM can successfully detect Giant Viruses like the Tupan virus by FM while simultaneously providing information on the EM ultrastructure of the Tupanvirus capsid and tail features.
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