Life sciences

Look into sub-cellular structures and gain insight into cellular mechanisms effortlessly

Understand the structure and the basic units of cells in a streamlined cryo-electron tomography (cryo-ET) workflow.

Check our cryo-CLEM solutions
What can we help you with?
  • Get high-resolution 3D structure of a protein complex in its near-native conformation
  • Obtain tomography data quickly with in-situ cryo-correlative light and electron microscopy
  • Keep cryo-samples vitrified and ice contamination-free at ease
  • Spend more time on analysis, and less on imaging your lamellae
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Prepare biological samples in one system

Studying cryogenic samples at the nanoscale is crucial in life sciences, since the basic elements of life are governed by nanoscale processes. An in-depth understanding of the processes that occur within a cell, tissue or a whole organ, for instance, is impossible without in-depth knowledge of the structures and composition. Cryo-electron tomography (cryo-ET) offers an unprecedented ability to visualize spatial and organizational relationships of biological macromolecules in their native state and environment, including viruses, cells and their organelles, and even tissues and multicellular organisms. However, as a cutting-edge technique in its early stages of development, cryo-ET is also highly complex as it consists of many steps that can be challenging to execute without error even for experienced practitioners.

The major difficulty in cryo-ET is finding the right region of interest in a frozen sample. Our integrated cryo-correlative light and electron microscopy (cryo-CLEM) solution enables in-situ cryo-CLEM to greatly enhance the region of interest (ROI)  targeting inside the focused ion beam/scanning electron microscope (FIB/SEM) while reducing the number of handling steps required. To help you keep samples vitrified and ice contamination-free, we developed a series of ice defence tools to minimize the undesired ice growth at every step of your cryo-electron microscopy workflow.

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What we can offer:

Effortless and fast workflows

Image structures and processes within cells simultaneously without switching microscopes

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Gain time and cost efficiencies

Analyze high-quality lamellae efficiently with less cryo-TEM time

Icon_CRYOBlue_Increase sample yield
Powerful insights from higher cryo-sample yield

Obtain insight into your biological system with minimum sample damage

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Support of our application experts

Get the most of your instrument with our guidance and help

What can you achieve by using integrated CLEM?

Our integrated cryo-CLEM system is the world-first commercially available fluorescent light microscope (FLM) that can be integrated into a cryo-FIB/SEM, which directly cuts down the steps  in the current cryo-ET workflow and thus increases workflow and cost efficiencies. Together with our CERES Ice Defence System protecting your samples from ice contamination at every step of the workflow, your sample yield will be dramatically increased. Our cryo-EM solutions will empower you:

  • Prepare lamellae in a seamless and simplified workflow
  • Obtain world-class results with optimized efficiency
  • Be the first one to answer fundamental biological questions
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METEOR (fluorescent light microscope) image of a 1 μm thick lamella of yeast overexpressing eGFP-Ede1 with the SEM image (left) overlaid. Images courtesy of A. Bieber, C. Capitanio and O. Schioetz (MPI Biochemistry)
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METEOR has the potential to drastically improve our sample yield, especially when dealing with bright and abundant fluorescence targets. Anyone who wants to perform correlative cryo-FIB milling can benefit from an integrated FLM system...

Anna Bieber and Cristina Capitanio


Max Planck Institute of Biochemistry

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