DELPHI is an extremely powerful and easy to use system, integrating a tabletop scanning electron microscope (SEM) with an inverted fluorescence microscope (FM). With this integration you can correlate two different types of information on the exact same cell, tissue or structure of interest. The system is extremely easy to use for both light and electron microscopy users. Because of a greatly simplified workflow you need to only load the sample once to obtain fluorescence and electron images. DELPHI opens the door to these techniques for all laboratories through a cost-efficient package that does not require experienced microscopy skills to acquire and interpret data.