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SECOM

Streamline your CLEM workflow

Combine the functional information from fluorescence microscopy and the ultrastructural information from electron microscopy for powerful insights into your biological system.

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Integrated correlative light and electron microscopy

Seamlessly switch between fluorescence and electron imaging with the SECOM, a high-end optical microscope for integrated correlative light and electron microscopy (CLEM). Eliminate the need to shuttle a sample between two systems and perform lengthy correlations between light and electron microscopy images. Speed up and simplify your CLEM workflow with the integration of two imaging modalities in a single device.

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Advantages of SECOM

Simplified CLEM workflow

Seamless switch between modalities

High-quality optics

Easy integration

Perform high-quality correlative microscopy

Perform correlative microscopy extremely fast without compromising either optical or electron performance. The SECOM comes with the highest optical quality and automated high-accuracy overlay. The use of fiducials is not required, ensuring versatility, efficient measurements, and minimal impact on your sample.

Easy integration

The SECOM is a fully equipped high-end optical microscope that can easily be integrated into an existing CLEM workflow and installed as a retrofit to your SEM. The SECOM platform is accompanied by ODEMIS, a powerful open-source acquisition software, which helps you analyze the overlaid image and draw significant scientific conclusions.

Results

Imaging with SECOM

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Cancer research

Localization of the lipid diacylglycerol within cellular membranes of HeLa cell expressing GFP-C1. Sample courtesy of C.J. Peddie & L.M. Collinson (2014)

Marine microbiology

Fluorescence image of marine microbes. Sample courtesy of S. Littman

Virology

Widefield fluorescence image of Tupan-virus containing cells. Sample courtesy of J.P. Baudoin (AP-HM)

Neuroscience

Projection neurons in songbird brain. Overlay of fluorescence and electron images with the injected tracer clearly visible. Sample courtesy of Thomas Templier (ETH Zurich)

Geology

Widefield (left) and superresolution (right) images localizing YFP-A3 in HeLa cells. Sample courtesy C.J. Peddie (Francis Crick Institute)

Type 1 diabetes

Rat pancreas data captured using the EM and SECOM system. Sample courtesy: B.N.G. Giepmans & P. de Boer, UMCG.

Cell biology

Dolichospermum and Aphanizomenon together with dinoflagellates and a diatom from the Baltic Sea. Sample courtesy of Sten Littman (MPI Bremen)

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Reach out to our team of specialists to find out how METEOR can help you improve your cryo-electron tomography workflow.

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Trusted by researchers in the field

“The precise overlay of SECOM is particularly important when there is no prior knowledge of fluorophore localization because it removes operator bias in the alignment process.”

Dr. Lucy M. Collinson Francis Crick Institute

“It gives us the possibility to identify different types of bacteria in environmental samples by the hybridization of these cells with specific HRP probes, after which we image them with the SEM and perform elemental analysis, including elemental analysis with EDX.”

Dr. Sten Littman Max Planck Institute for Marine Microbiology