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Cryo Solutions

METEOR: an integrated top down cryo-CLEM imaging system

Optimize the cryo-ET workflow by reducing complicated transfer steps and increasing sample yield

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Fluorescence light microscope (FLM) integrated into a FIB/SEM system

METEOR overcomes the challenges in the current cryogenic electron tomography (cryo-ET) workflow by providing the capability to perform in situ fluorescence light microscopy (FLM) in your cryo focused ion beam (FIB)/ scanning electron microscope (SEM) chamber. Not only does it reduce the number of transfer steps between microscopes, protecting the fragile sample from unnecessary contamination, it will also allow you to confirm the presence of the region of interest (ROI) in the lamella directly after FIB milling. METEOR is highly adaptable to your current workflow and works well with your transfer systems and sample holders, making it easy to adopt.

METEOR can ensure an efficient workflow and increased sample yield for downstream acquisition of high resolution three-dimensional biological structures in their near-native cellular environment. It’s a powerful tool that can be applied to a wide range of research areas including microbiology, neurosciences, immunology, virology, developmental, cell, and molecular biology.

This product is supported by the Eurostars grant № E13008 - CETFlow.

Key advantages

Increase sample yield with integrated cryo-FLM system
Increase sample yield

Target your ROIs more effectively and update your FIB milling strategy during lamella fabrication with an integrated FLM. Reduce transfer steps and thereby sample damage.



Have both FLM and FIB within the same microscope
Optimize your workflow

Save time and work more efficiently by having both FLM and FIB in the same microscope.

Obtain insights and get tomography data faster
Boost productivity

Produce high-quality lamellae more easily. Obtain insight into your biological system through getting useful tomography data more quickly.

Integrated cryo-FLM for ROI finding
Improve cost efficiencies

Use your cryo-TEM time more effectively by inspecting lamellae for fluorescence signals directly after milling.

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Working with METEOR

The METEOR system directly cuts down the steps in the current cryo-ET workflow and thus increases workflow and cost efficiencies.

Photo_Anna, Cristina, Oda

METEOR has the potential to drastically improve our sample yield, especially when dealing with bright and abundant fluorescence targets. Anyone who wants to perform correlative cryo-FIB milling can benefit from an integrated FLM system...

Anna Bieber and Cristina Capitanio


Max Planck Institute of Biochemistry

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Can I use METEOR for my research?

METEOR is a powerful system to facilitate the studies of biological samples in their near-native cellular environment. METEOR can be applied to a wide range of research areas, such as neuroscience, cell biology, and virology. Above all, METEOR is easily adaptable to your sample preparation workflow, whether you work with plunge frozen or high-pressure frozen samples, perform on-grid milling or lift-out.

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