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Cryo Solutions

METEOR: an integrated top down cryo-CLEM imaging system

Improve the cryo-ET workflow efficiency and streamline cryo-CLEM with in situ fluorescence imaging

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Fluorescence light microscope (FLM) integrated into a FIB/SEM system*

METEOR overcomes the challenges in the current cryogenic electron tomography (cryo-ET) and cryo correlative light and electron microscopy (cryo-CLEM) workflows by providing the capability to perform in situ fluorescence light microscopy (FLM) in your cryo focused ion beam (FIB)/ scanning electron microscope (SEM) chamber. In addition to reducing the number of transfer steps between microscopes, protecting the fragile sample from unnecessary contamination, METEOR allows you to collect fluorescence signals from the samples directly after milling. For cryo-ET you can confirm the presence of the region of interest (ROI) in the lamella to better spend your cryo-transmission electron microscope (TEM) time. For the volume cryo-CLEM workflow you can acquire better resolution FLM images throughout the depth of the sample. METEOR is highly adaptable to your current workflow and works well with your set-up, making it easy to adopt.

METEOR can increase the cryo-ET sample yield, which allows you to resolve three-dimensional biological structures in their near-native cellular environment at a sub-nanometre resolution downstream more efficiently. It can also provide a more streamlined CLEM workflow and correlate functional and structural information of the whole cell more easily. METEOR is a powerful tool that can help enhance our knowledge in a wide range of life science research areas including neurosciencesmicrobiology, virology, immunology, developmental, cell, and molecular biology.

This product is supported by the Eurostars grant № E13008 - CETFlow.

* Compatible systems

Key advantages

Increase sample yield with integrated cryo-FLM system
Increase sample yield

Target your ROIs and correlate better and more effectively with the integrated FLM. Reduce transfer steps and thereby sample damage.



Have both FLM and FIB within the same microscope
Optimize your CLEM workflow

Collect FLM images more efficiently from the core of the sample or the lamella as materials are milled away.

Obtain insights and get tomography data faster
Boost productivity

Produce high quality lamellae more easily. Obtain insight into your biological system through getting useful tomography data more quickly.

Icon_CRYOBlue_Cost Efficiency
Improve cost efficiencies

Use your cryo TEM time more effectively on useful lamellae. Remove the need for a separate cryo FLM dedicated solely to ROI finding.

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Working with METEOR

The METEOR system directly cuts down the steps in the current cryo-ET workflow and thus increases workflow and cost efficiencies.

Photo_Anna, Cristina, Oda

METEOR has the potential to drastically improve our sample yield, especially when dealing with bright and abundant fluorescence targets. Anyone who wants to perform correlative cryo-FIB milling can benefit from an integrated FLM system...

Anna Bieber and Cristina Capitanio


Max Planck Institute of Biochemistry

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Can I use METEOR for my research?

METEOR is a powerful system to facilitate the studies of biological samples in their near-native cellular environment. METEOR can be applied to a wide range of research areas, such as neuroscience, cell biology, and virology. Above all, METEOR is easily adaptable to your sample preparation workflow, whether you work with plunge frozen or high-pressure frozen samples, perform on-grid milling or lift-out.

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