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FAST-EM
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High image acquisition with 64 parallel electron beams and short dwell times
Ultra-fast automated electron microscope
Image biological thin samples at unprecedented speeds, with a level of automation that enables large-scale imaging without the need for constant supervision.
In a nutshell
- Speed up your EM workflow
- Enable large-scale imaging
- Get more statistically sound conclusions
Large-scale imaging with nanometer resolution
FAST-EM, an ultra-fast automated multibeam electron microscope, enables large-scale EM imaging. It makes it possible to compare the ultrastructure of healthy and diseased tissue and perform screens on drug treatments, all while retaining nanometer-range resolution. It enables a rapid, unbiased method of data collection, without constant supervision. FAST-EM is also highly beneficial for volume-EM, as larger volumes can be imaged within a shorter amount of time. This opens the way to ever-larger projects, such as imaging an entire hemisphere or even an entire mouse brain for connectomics.
FAST-EM in action
FAST-EM was designed together with ThermoFisher, Technolution, and TU Delft to make complex EM workflows simple and efficient. The system uses optical Scanning Transmission Electron Microscopy (STEM) for image formation, for which the samples need to be collected on scintillators. The FAST-EM allows for the loading of up to nine scintillator substrates at the same time.
To achieve high-throughput imaging, FAST-EM uses 64 electron beams, which are scanned over the sample in parallel. The reliability of the microscope and the software allow the operator to leave the system running without constant supervision, allowing you to shift the focus from microscope operation to data analysis.
Key features of FAST-EM
64 parallel electron beams
Rigid uniform substrate
The scintillator screen allows the loading of up to nine substrates at the same time
STEM imaging
Collect nanoscale detail while retaining the larger context of the sample
Robust automation software
Leave the system to automatically acquire complex datasets without constant supervision
FAST-EM offers new possibilities for my field of research - correlative light electron microscopy, especially in terms of neurons or system development. The electron microscope is now going to give volumes and areas that used to be the domain of light microscopy only.
Dr. Jacob Hoogenboom
-Faculty of Applied Sciences, TU Delft
Blog highlight
Volume electron microscopy: how can biologists gain insights using automated segmentation of organelles?
Talk to an expert
Get in touch with one of our experts to get more information. Call +31 (0)15 744 01 58 or book a meeting on their agenda.
