Armed with the CERES Ice Shield, the New York Structural Biology Center was able to protect lamellae from ice contamination and achieve both an increase in lamellae production and resolution.
Download this material to learn more about each step of the FAST-EM workflow, its advantages and how it can take your research from sample to insights significantly faster.
Learn about integrated correlative light and electron microscopy for studying Type 1 diabetes.
Read how best overlay accuracy in correlative microscopy can be achieved when acquiring fluorescence and electron images on the same resin-embedded section.
Read how integrated correlative light and electron microscopy (CLEM) reveals the giant virus particles by fluorescence light microscopy (LM) while simultaneously providing information on the ultrastructure with electron microscopy (EM).
Learn how Super-resolution (SR) light microscopy and electron microscopy (EM) together revolutionize our understanding of biological systems, providing highly accurate correlation of fluorescent proteins with cellular structure.
Learn about the possibilities of integrated correlative light and electron microscopy for studying and understanding marine microbes.
Learn how integrated correlative light and electron microscopy can be beneficial for understanding synaptic connectivity and large-scale interactions in the brain.
Learn about the concept of correlative light-electron microscopy (CLEM) and how it can be used for various applications in the life sciences.
Learn about the relevance of CLEM in the life sciences, as well as some of the challenges such as overlaying images and retrieving regions of interest.
Learn about how to set up imaging conditions to obtain high quality CL intensity maps and spectra from a range of materials
Learn about the difference between coherent and incoherent CL emission, how it can be identified and what each type of the emission can be used for.
Learn about the possibilities of integrated CLEM for studying giant viruses, which are found in environmental, animal, as well as human samples.
Learn in details about the possibilities of CL imaging for measuring and analysing thin-film solar cells and various materials used in the photovoltaic industry, this is the webinar for you.
Learn about how the measurement of cathodoluminescence emission can be applied in nanoscale optics, geology, and materials science.
Learn about exploration of microstructure and chemistry in minerals using EBSD and CL techniques.
Learn about the different types of cathodoluminescence (CL) and more specifically, how angle-resolved CL is performed.
Learn more the physical background of cathodoluminescence emission in rocks, sample preparation, and the typical CL workflow.
Learn more the properties of ligh, the dynamics in materials, time-resolved imaging techniques (including lifetime imaging and g(2) imaging) and examples of how these technique can be applied to study nanostructured semiconductors.
Learn more the fundamentals of cathodoluminescence for rare-earth doped materials
Learn how cathodoluminescence can be used to retrieve optical properties of plasmonic materials with the deep-subwavelength resolution.
A comprehensive overview of the cathodoluminescence technique, latest developments and various applications.
Learn about the principle of operation, details of CLEM, hardware, open source software-based operation and scripting, as well as sample preparation.
Read this application note to learn how cathodoluminescence is used as a prescreening tool for high-resolution secondary-ion- mass spectrometry (SIMS) to image the zonation pattern and identify regions of interest for isotope analysis of geological samples, such as zircons.
Learn more the physical background of CL emission, sample preparation, and the typical CL workflow.
Learn about the possibilities of energy-momentum cathodoluminescence for acquiring hybrid multidimensional high-resolution angle-resolved hyperspectral datasets in the fields of nanophotonics and materials science.
Read how cathodoluminescence can be used for retrieving optical properties of photonic crystals with deep-subwavelength resolution.
Learn why and how cathodoluminescence imaging can be used to directly visualize the internal modal structure of semiconductor nanoparticles.
Learn about the fastest and simplest method to obtain cathodoluminescence contrast: intensity mapping.
Learn how cathodoluminescence imaging and spectroscopy is used extensively to study GaN materials and devices.
Learn how cathodoluminescence imaging and spectroscopy is used to study perovskite materials.
Rare earth materials are a particular class of elements in the periodic table which serve a range of practical uses. Learn how cathodoluminescence can be used to study these materials.
Learn how cathodoluminescence imaging and spectroscopy is used extensively to study properties of thin-film solar cells.
Learn how cathodoluminescence (CL) imaging and spectroscopy provides a powerful method to study the optical properties of 3D perovskites structures on deep-subwavelength scales.
Read this technical note to learn how accurate and unbiased overlay is achieved in SECOM, an integrated correlative light and electron microscope.
Learn the possibilities of angle-resolved imaging mode available in Delmic CL solutions.
Learn the possibilities of hyperspectral imaging mode available in Delmic CL solutions.
Learn the possibilities of polarization-filtered cathodoluminescence imaging mode available in Delmic CL solutions.
Learn the possibilities of cathodoluminescence intensity imaging mode available in Delmic CL solutions.
Read more about the optical modules of the SPARC Spectral and Compact systems, which can be configured for various detection functionalities and wavelength ranges.
Learn about lifetime (or decay trace) mapping which can help to identify a material defect and to characterize materials to improve their performance.
Learn about the possibilities of hyperspectral CL imaging for spatially extended specimen such as zircons and other minerals.
Learn how cathodoluminescence spectroscopy can be used for micro-characterization of rocks and minerals, and how this technique can be employed to study quartz sandstone.
Read about the possibilities of cathodoluminescence imaging for studying meteorite impacts in shocked quartz grains.
Read about the research on studying alluvial sapphires from Australia to learn how cathodoluminescence can help to assess crystallisation histories of the precious gemstones and underlying causes for luminescence.
Check exact specifications of the SPARC Spectral, a high-performance cathodoluminescence detector, in the product brochure.
Check exact specifications of the SPARC Compact, the cathodoluminescence detector, in the product specifications sheet.
Check exact specifications of integrated correlative light and electron microscope SECOM in the product brochure.
Watch the video to learn the main advantages of the SPARC Spectral system.
Use the databased of Monte Carlo beam tracing simulations for incoherent CL emission for most commonly studied materials to learn how you can set up optimal imaging conditions for your experiments.
Learn about time-resolved cathodoluminescence imaging, which can be extremely valuable for a large range of applications.
Learn the possibilities of lens-scanning energy-momentum imaging mode available in Delmic CL solutions.
In this white paper, we discuss several methods to ensure an integrated imaging workflow, and present results obtained using a variety of techniques and samples.
Get all specifications of the SPARC Spectral cathodoluminescence detector to get full information about the system.
Get all specifications of the panchromatic and RGB cathodoluminescence detector to get full information about the system.
Learn more about SPARC Spectral module for time-resolved cathodoluminescence: lifetime and g(2) imaging.
Watch the video to learn about the main advantages of the SECOM system.
What is time-resolved cathodoluminescence? How can it be applied to your research? In this video, Toon Coenen gives an in-depth explanation of this imaging technique.
What is Correlative Light and Electron Microscopy? And how does it work? Why do we combine fluorescence microscopy and electron microscopy? And what are the key advantages of using this technique? Watch the video with Delmic application specialist, Sangeetha Hari.
Time-resolved cathodoluminescence imaging is now available in one solution: the LAB Cube. Delmic is presenting a unique system, which allows performing g(2) and lifetime imaging.
The youngest member of Delmic's cathodoluminescence (CL) solutions family, JOLT is an entry-level SEM-based cathodoluminescence detector, which is ideal for CL intensity mapping.
This CL webinar series will go back to the basics of cathodoluminescence imaging and cover its fundamentals as well as the new research directions in six webinar sessions.
Meet our customer, Prof. Cameron Davidson, who is currently working at the Department of Geology, Carleton College.
Meet our customer, Dr. Ruggero Verre, who is a post-doctoral researcher in the Department of Applied Physics - Division of Bionanophotonics at the Chalmers University of Technology in Gothenburg in southern Sweden.
Meet our customer, Dr. Sten Littman, who is a scientist working at the department of biogeochemistry in MPI for Marine Microbiology in Bremen.
Meet our customer, Dr. Lindgren, who has worked previously as a senior engineer at Sol Voltaics, a start-up which produced solar cells out of nanowires with a new technique called Aerotaxy.
Our application specialist Marit Smeets gives an overview of all the steps that are involved in the current sample preparation method, specifically focusing on the role of cryo fluorescence light microscopy (cryo-FLM). We also discuss integrated cryo-FLM and how it can make the workflow easier and more efficient.
Learn more about our new integrated cryo-FLM system for FIB/SEM which helps you to make the cryo-CLEM workflow less complex.
Together with our applications specialist Job Fermie you will dive deep into current challenges of electron microscopy and what would be possible without major limitations.
Our Applications Specialist Sangeetha Hari will introduce the importance of sample preparation for acquiring high quality CL data and describe different sample preparation techniques.
With this webinar, we want to give you a glimpse of what would be possible for your research with Delmic new FAST-EM system and what problems it will help to solve.
In the first episode of cryo-ET journal club, our application specialists, Marit Smeets and Caspar Jonker, primarily focus on how the authors used the combination of techniques and how they interpreted the data to come to their conclusions. The discussion touches upon the impact of the paper on cell biology and on cryo-ET technology development.
This webinar dives into how CL enables fast and high resolution imaging of large areas. The discussion primarily focuses on imaging and analysis techniques for the characterization of zircons and sedimentary rocks.
In this episode, our application specialists Marit Smeets and Caspar Jonker discuss two new preprints on bioRxiv, in which the structure and replication of coronaviruses are characterized using in-situ cryo-ET in combination with FIB milling.
Get to know the mechanism of cryo fluorescence light microscopy (cryo-FLM) working in cryogenic electron tomography (cryo-ET). Our application specialist Dr. Caspar Jonker introduced it all in two minutes and explained the possibility to improve the cryo-ET workflow with integrated cryo-FLM.
The need for increased throughput, automation and reliability in electron microscopy has shown the need for a drastic new approach to large-scale imaging. Delmic’s FAST-EM system is the solution to overcome the challenges that make the EM a limiting factor for these projects.
Dr. Lucy M. Collinson and Dr. Christopher J. Peddie are researchers of the Electron Microscopy Science Technology Platform (EM STP) at The Francis Crick Institute in London, specializing particularly in correlative and volume imaging of cells and tissues.
In this webinar our applications specialist Job Fermie shows the system's set up, explains how the samples are handled and how the multibeam is set up, generated and detected. We also give a preview of how the image is formed and what data can be acquired with the system.
Read this application note to learn how cathodoluminescence can be used for characterization of plasmonic nanoantenna properties.
Developing and producing efficient UV LED devices still poses a challenge. Read this application note to learn how cathodoluminescence can be used to inspect UVC LEDs.
In this webinar, our applications specialist Sangeetha Hari will present exciting results from CL imaging in the field of semiconductors, and explain the hardware and imaging parameters involved.
With the official launch of METEOR, we will be hosting two online demonstrations of the system: on the 28th October at 10 am (CET) and the 29th October at 6 pm (CET). It aims to give you a fully immersive online experience which enables you to know METEOR from all the perspectives. Join us to see how METEOR can help you overcome the challenges in the current cryogenic electron tomography workflow and make your research easier!
We are excited to invite you to the online demonstration of FAST-EM system, a groundbreaking solution that can image biological thin samples a hundred times faster than conventional EM. For the first time, we will be introducing the whole workflow of the system and demonstrating how seamless the next generation of microscopy can be. Reserve your spot in one of the two available sessions, on the 1st of 2nd of December.
Check out the optical path design of our new integrated cryo-FLM system for FIB/SEM which simplify your cryo-CLEM workflow and increase your lamella yield dramatically.
In this webinar our applications specialist Sangeetha Hari will talk about cathodoluminescence probes and exciting applications of CCLEM.
Learn all the technical aspects of FAST-EM in this specification sheet, including electron optics, scanning and detection, sample and stage, imaging workflow, software, vacuum and support hardware, as well as optional components.
In this journal club we discussed the article The In Situ Structure of Parkinson’s Disease-Linked LRRK2 that tackled this barrier using correlative light and electron microscopy, in situ cryo-electron tomography, and subtomogram analysis.
Dr. Jacob P. Hoogenboom is heading one of the ImPhys research groups at the Faculty of Applied Sciences at the TU Delft. The focus of his research group lies in the development of and research with new tools and techniques bridging the gap between light and electron microscopy.
Priv.-Doz. Dr. Daniel Abou-Ras, Dr. Klaus Schwarzburg and Dr. rer. nat. Sebastian Schmitt work at Helmholtz-Zentrum Berlin (HZB), a research centre that focuses on studying materials for a sustainable energy supply. Learn how they are using cathodoluminescence to study optoelectronic properties of semiconductor thin films at the nanoscale.
Check out this application note to learn about the potential of METEOR for simplifying the cryo-ET workflow by preparing targeted cryo-lamellae from Saccharomyces cerevisiae (yeast) overexpressing Ede1 tagged with enhanced green fluorescent protein (eGFP).
Our hosts discussed the workflow described by Wagner et al. and compared it to other workflows that have been described over time. Two of the authors, Reika Watanabe and Digvijay Singh, also joined the Q&A session and answered some interesting questions.
In this webinar, our application specialist Caspar Jonker introduced the crucial steps in the workflow that contribute most to sample ice contamination, and most importantly, the new developments that aim to minimize contamination in cryo-ET altogether.
Dr. Sebastian Tacke and his colleagues working at Max Planck Institute of Molecular Physiology (MPI) innovated the Cryo Workflow Tools, commercially known as CERES Ice Defence System. With the powerful tools, the lab streamlined the cryo-FIB/SEM automation process and reduced the frost contamination by 50% .
Meet CERES Ice Defence System by Delmic: powerful tools for minimizing ice contamination. Obtain better quality cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) results, higher throughput, and higher resolution.
Download this brochure to learn more about how CERES Ice Defence System, the series of powerful tools, which minimize ice contamination and help you obtain the highest quality cryo-EM samples, with higher throughput and world-class results.
In this Journal Club, our hosts Dr. Caspar Jonker and Marit Smeets will discuss α-Syn aggregates, which consist of cellular organelles and α-Syn fibrils as shown in the article "In situ architecture of neuronal α-Synuclein inclusions" .
During this webinar, we will show how CL spectroscopy of sub-micron sized particles can be used on a variety of plastics like polyethylene, PVC, polypropylene, teflon, and mixtures of these materials.
Anna Bieber, Cristina Capitanio and Oda Helene Schioetz are PhD candidates at the Max Planck Institute of Biochemistry in Martinsried, Germany. By implementing METEOR, they improved the existing workflow to make correlative cryo-focused ion beam milling and cryo-ET more robust, more effective and easier to use.
Read the story of our customer, Dr. Saskia Fiedler. She is a Postdoc at SDU (University of Southern Denmark) Nano Optics and The Mads Clausen Institute. Her research is focused on electron beam-based spectroscopy, namely CL and EELS, of plasmonic and dielectric nanostructures.
Read the application note to learn how to quantitatively characterize a variety of micro and nanoplastic materials with CL
In the third episode of the R&D series "Unlocking the power of cryo-ET", our Mechanical Designer Keith Baelz talked about how we developed the new transfer mechanism to address the shortcomings in the traditional cryo sample transfer workflow.
In this introduction episode of the R&D series "Unlocking the power of cryo-ET", we talk about the reasons why we started our journey. Watch the video to learn how we are going to revolutionize cryo-ET technology and make sure that researchers achieve scientific breakthroughs faster and easier.
In the fourth episode of the R&D series "Unlocking the power of cryo-ET", our Application Specialist Caspar Jonker introduced how this micro cooler is designed and placed in the FIB/SEM chamber of our fully automated cryo-CLEM system.
Get to know Cryogenic electron tomography (cryo-ET), the very powerful technique in two minutes! This technique is becoming more and more important since knowing the location as well as the structure of proteins is crucial for understanding their cellular function.
Download this material to learn more about the CERES Clean Station workflow. Get the technical specifications of the Clean Station and learn how it protects your sample at each step of the workflow.
Would you like to make statistically significant conclusions from your EM data, whether that is in pathology, connectomics, toxicology, or cell biology? In this webinar, the Business Unit Owner of Delmic Fast Imaging, Guido Ridolfi, will talk about what could be possible with next-generation electron microscope, FAST-EM.
Would you like to increase your success rate to safely prepare a clean, usable cryo sample? In this webinar our Application Specialist Marit Smeets will discuss the crucial steps in the cryo-ET workflow that contribute most to sample contamination and dive into the new developments that allow reduction of contamination in Cryo-ET altogether. She will present our all-in-one solution: the CERES Ice Defence System.
Download this brochure to learn more about FAST-EM, an ultra-fast automated multibeam electron microscope.
In this webinar, our Application Specialist Sangeetha Hari focuses on CL imaging for the characterization of LEDs and single-photon devices. She gives practical examples of the two applications that acquired quantitatively comparable data and characterized LEDs from the deep UV to the infrared.
Download the brochure to learn more about METEOR, the award-winning fluorescence light microscope that allows monitoring the presence of the target signal during and after milling within the FIB chamber.
Sample preparation is an important part of the electron microscopy workflow. Read the white paper where we discuss the current challenges of sample preparation for electron microscopy and demonstrate how easy it is to use existing automated techniques for sample preparation in combination with FAST-EM.
Download the application note and learn about the possibilities of cathodoluminescence imaging on unicellular marine organisms.
Learn more about how to prevent in-chamber ice contamination with CERES Ice Shield.