Image structures and processes within cells simultaneously without switching microscopes
Cathodoluminescence solutions that reveal fundamental properties of matter
Fast EM solutions for reliable and high throughput electron microscopy
Integrated correlative microscopy solutions that combine the power of fluorescence and electron microscopy
Cathodoluminescence solutions that reveal fundamental properties of matter
Fast EM solutions for reliable and high throughput electron microscopy
Integrated correlative microscopy solutions that combine the power of fluorescence and electron microscopy
Studying samples at the nanoscale is crucial in life sciences, since the basic elements of life are governed by nanoscale processes. An in-depth understanding of the processes that occur within a cell, tissue or a whole organ, for instance, is impossible without in-depth knowledge of the structures and composition. Different microscopy techniques have been used to explore the different aspects such as structure, composition and function. Fluorescence microscopy excels at tracking dynamic processes and identifying specific proteins, while electron microscopy provides high-resolution structural information.
Electron microscopes can be used to collect high-resolution data in large-scale projects. Fast-EM or Fast SEM imaging is perfect for these projects, as whole organs and tissues at high resolution at much faster rates than conventional SEMs allow.
By combining EM and FM in integrated correlative light and electron microscopy (iCLEM), the labeling specificity of FM can be combined with the structural information of EM. iCLEM therefore provides the precise location of a protein within the structural context of the sample.
Image structures and processes within cells simultaneously without switching microscopes
Reduce time spent by operators on acquisition and dedicate it to analysis
Fast microscopy solutions for large volume imaging of tissues or even organs
Get the most of your instrument with our guidance and help
The integrated CLEM is the first solution that combines EM and FM in one device. This solution allows seamless acquisition of both functional and structural data, does not require the use of fiducials, and thus ensures more efficient measurements and a limited impact on your sample. No more time-consuming and possibly damaging switches from one microscope to another and no more frustrating manual overlay used in the traditional CLEM procedures. The integrated CLEM enables you:
Dr. Lucy M. Collinson and Dr. Christopher J. Peddie
-Francis Crick Institute