Life sciences

Look into cellular structure and function effortlessly

Understand the structure and composition of cells and speed up image acquisition for large scale samples with our powerful microscopy solutions.

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What can we help you with?
  • Acquiring structural and functional information of cells simultaneously
  • Automatically overlaying fluorescence and electron microscopy images 
  • Imaging larger areas faster and with high resolution
  • Spending more time of analysis, and less on imaging your samples
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Study complex and large biological samples

Studying samples at the nanoscale is crucial in life sciences, since the basic elements of life are governed by nanoscale processes. An in-depth understanding of the processes that occur within a cell, tissue or a whole organ, for instance, is impossible without in-depth knowledge of the structures and composition. Different microscopy techniques have been used to explore the different aspects such as structure, composition and function. Fluorescence microscopy excels at tracking dynamic processes and identifying specific proteins, while electron microscopy provides high-resolution structural information.

Electron microscopes can be used to collect high-resolution data in large-scale projects. Fast-EM or Fast SEM imaging is perfect for these projects, as whole organs and tissues at high resolution at much faster rates than conventional SEMs allow.

By combining EM and FM in integrated correlative light and electron microscopy (iCLEM), the labeling specificity of FM can be combined with the structural information of EM. iCLEM therefore provides the precise location of a protein within the structural context of the sample.

What we can offer:

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Effortless and fast workflows

Image structures and processes within cells simultaneously without switching microscopes

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More time spent analyzing than imaging

Reduce time spent by operators on acquisition and dedicate it to analysis

FeatureIcon_CLEM_SVG_270x270_image and inspect large areas
Powerful insights into large-scale samples

Fast microscopy solutions for large volume imaging of tissues or even organs

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Support of our application experts

Get the most of your instrument with our guidance and help

What can you achieve by using integrated CLEM?

The integrated CLEM is the first solution that combines EM and FM in one device. This solution allows seamless acquisition of both functional and structural data, does not require the use of fiducials, and thus ensures more efficient measurements and a limited impact on your sample. No more time-consuming and possibly damaging switches from one microscope to another and no more frustrating manual overlay used in the traditional CLEM procedures. The integrated CLEM enables you:

  • Study the intricate relation of form and function in biology easily
  • Achieve more in your biological research with powerful insights
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Localization of the lipid diacylglycerol within cellular membranes of HeLa cell expressing GFP-C1, imaged with the SECOM correlative light and electron microscope at the Francis Crick Institute for research on cancer.
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At our EM Science Technology Platform, [...] we use the SECOM SR platform to perform high accuracy CLEM experiments on resin-embedded cells and tissues containing fluorescent proteins. Implementing superresolution localisation microscopy in the SECOM SR using the blinking of standard fluorescent proteins in-resin takes us to the next level.

Dr. Lucy M. Collinson and Dr. Christopher J. Peddie

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Francis Crick Institute

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Talk to an expert

Get in touch with our applications specialist Caspar to get more information.
Call +31 (0)15 744 01 58 or book a meeting on his agenda.

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