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Cryo electron microscopy

Cryo-ET publications

Stay updated with the most interesting publications on cryogenic electron microscopy in the life sciences. Check the whole list below.

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The promise and the challenges of cryo-electron tomography
Turk, M., and Baumeister, W., FEBS letters 594(20), pp. 3243–3261. (2020) 

Advances in cryo-electron tomography for biology and medicine
Koning, R. I., Koster, A. J., and Sharp, T. H., Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 217, pp. 82–96. (2018) 

Fine details in complex environments: the power of cryo-electron tomography
Hutchings, J., and Zanetti, G., Biochemical Society Transactions. Portland Press Ltd, 46(4), pp. 807–816. (2018) 

Towards Visual Proteomics at High Resolution
Bäuerlein, F. J. B., and Baumeister, W., Journal of molecular biology 433(20). (2021) 

Deciphering the molecular architecture of membrane contact sites by cryo-electron tomography
Collado, J., and Fernández-Busnadiego, R., Biochimica et biophysica acta. Molecular cell research 1864(9), pp. 1507–1512. (2017) 

Calling cell biologists to try cryo-ET 
Marx, V., Nature Methods 2018 15:8. Nature Publishing Group, 15(8), pp. 575–578. (2018) 

Cellular and Structural Studies of Eukaryotic Cells by Cryo-Electron Tomography
Weber, M. S., Wojtynek, M., and Medalia, O., Cells. Multidisciplinary Digital Publishing Institute (MDPI), 8(1), p. 57. (2019) 

Cryo-Electron Tomography and Subtomogram Averaging 
Wan, W., and Briggs, J. A. G., Methods in enzymology. Methods Enzymol, 579, pp. 329–367. (2016) 

Technology and methods

A streamlined workflow for automated cryo focused ion beam milling
Tacke, S., et al., Journal of Structural Biology. Academic Press, 213(3), p. 107743. (2021) 

Sample Preparation by 3D-Correlative Focused Ion Beam Milling for High-Resolution Cryo-Electron Tomography
Bieber, A., et al., Journal of visualized experiments: JoVE. J Vis Exp, (176). (2021) 

Preparing samples from whole cells using focused-ion-beam milling for cryo-electron tomography
Wagner, F. R., et al., Nature protocols. Nat Protoc, 15(6), pp. 2041–2070. (2020) 

A cryo-FIB lift-out technique enables molecular-resolution cryo-ET within native Caenorhabditis elegans tissue
Schaffer, M., et al., Nature methods. Nat Methods, 16(8), pp. 757–762. (2019)

PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy
Gorelick, S., et al., eLife. eLife Sciences Publications Ltd, 8. (2019)

Structural analysis of multicellular organisms with cryo-electron tomography
Harapin, J., et al., Nature methods. Nat Methods, 12(7), pp. 634–636. (2015)

Rapid tilt-series acquisition for electron cryotomography
Chreifi, G., et al., Journal of structural biology. J Struct Biol, 205(2), pp. 163–169. (2019)

Integrated Cryo-Correlative Microscopy for Targeted Structural Investigation In Situ
Smeets, M., et al., Microscopy Today. Cambridge University Press, 29(6), pp. 20–25. (2021)

Fluorescence-guided lamella fabrication with ENZEL, an integrated cryogenic CLEM solution for the cryo-electron tomography workflow
Jonker, C., et al., Microscopy and Microanalysis. Cambridge University Press, 27(S1), pp. 3234–3235. (2021)

In situ structure of virus capsids within cell nuclei by correlative light and cryo-electron tomography
Vijayakrishnan, S., et al., Scientific reports. Sci Rep, 10(1). (2020)

Cryo-correlative light and electron microscopy workflow for cryo-focused ion beam milled adherent cell
Klein, S., et al., Methods in cell biology. Methods Cell Biol, 162, pp. 273–302. (2021)

Automated cryo-lamella preparation for high-throughput in-situ structural biology
Buckley, G., et al., Journal of structural biology. J Struct Biol, 210(2). (2020)

Multi-scale 3D Cryo-Correlative Microscopy for Vitrified Cells
Wu, G. H., et al., Structure (London, England : 1993). Structure, 28(11), pp. 1231-1237.e3. (2020)

Fully automated, sequential focused ion beam milling for cryo-electron tomography
Zachs, T., et al., eLife. Elife, 9. (2020)

Convolutional neural networks for automated annotation of cellular cryo-electron tomograms
Chen, M., et al., Nature methods. Nat Methods, 14(10), pp. 983–985. (2017)

Micropatterning Transmission Electron Microscopy Grids to Direct Cell Positioning within Whole-Cell Cryo-Electron Tomography Workflows
Sibert, B. S., et al., JoVE (Journal of Visualized Experiments). Journal of Visualized Experiments, 2021(175), p. e62992. (2021)

Robust workflow and instrumentation for cryo-focused ion beam milling of samples for electron cryotomography
Medeiros, J. M., et al., Ultramicroscopy. Ultramicroscopy, 190, pp. 1–11. (2018) 


Structures and distributions of SARS-CoV-2 spike proteins on intact virions
Ke, Z., et al., Nature. Nature, 588(7838), pp. 498–502. (2020)

Visualizing the molecular sociology at the HeLa cell nuclear periphery
Mahamid, J., et al., Science (New York, N.Y.). Science, 351(6276), pp. 969–972. (2016)

The molecular basis for sarcomere organization in vertebrate skeletal muscle
Wang, Z., et al., Cell. Cell, 184(8), pp. 2135-2150.e13. (2021)

Complete atomic structure of a native archaeal cell surface
von Kügelgen, A., Alva, V., and Bharat, T. A. M., Cell Reports. Elsevier, 37(8), p. 110052. (2021)

Electron cryo-tomography reveals the subcellular architecture of growing axons in human brain organoids
Hoffmann, P. C., et al., Cell Reports. Elsevier, 37(8), p. 110052. (2021)

Viral Capsid Trafficking along Treadmilling Tubulin Filaments in Bacteria
Chaikeeratisak, V., et al., Cell. Cell, 177(7), pp. 1771-1780.e12. (2019)

A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits
Wilfling, F., et al., Molecular cell. Mol Cell, 80(5), pp. 764-778.e7. (2020)

Visualizing virus assembly intermediates inside marine cyanobacteria
Dai, W., et al., Nature. Nature, 502(7473), pp. 707–710. (2013)

Assembly of a nucleus-like structure during viral replication in bacteria
Chaikeeratisak, V., et al., Science (New York, N.Y.). Science, 355(6321), pp. 194–197. (2017)

In Situ Architecture and Cellular Interactions of PolyQ Inclusions
Bäuerlein, F. J. B., et al., Cell. Cell, 171(1), pp. 179-187.e10. (2017)

In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment
Guo, Q., et al., Cell. Cell, 172(4), pp. 696-705.e12. (2018)

Three-Dimensional Structural Characterization of HIV-1 Tethered to Human Cells
Strauss, J. D., et al., Journal of virology. J Virol, 90(3), pp. 1507–1521. (2015)

The In Situ Structure of Parkinson’s Disease-Linked LRRK2
Watanabe, R., et al., Cell. Cell, 182(6), pp. 1508-1518.e16. (2020)

A molecular pore spans the double membrane of the coronavirus replication organelle
Wolff, G., et al., Science (New York, N.Y.). Science, 369(6509), pp. 1395–1398. (2020)