Integrated CLEM enables the study of rare and transient events occurring within the diseased cell at high resolution. This technique has great potential for shedding light on the process by which cancer develops and spreads.
Cancer research is an important field which investigates the causes of cancer and develops methods for treatment. The development and spread of cancer is a dynamic process which starts within the genes of a cell or a group of cells. Understanding these processes, which happen on a nanoscale level, is essential to developing methods that can limit the spread of cancer to other parts of the body.
Correlative light and electron microscopy (CLEM) has consistently been gaining popularity in the field of cancer research. The Delmic integrated CLEM enables the observation of very specific biochemical changes at the nanoscale by combining the labelling power offered by fluorescence microscopy with the high-resolution contextual information from the scanning electron microscope.
While using the SECOM, scientists were able to examine the loss of the SMAD4 gene in transfected and cultured colorectal cancer cells. The changes in cell shape and small cell protrusions were clearly observed, for instance, invadopodia degrades the extracellular matrix and contributes to metastasis. Researchers argue that it was only with a system that could perform high-aperture fluorescence and electron microscopy simultaneously that these changes in the cells could be observed.
Dr. Lucy M. Collinson and Dr. Christopher J. Peddie
-Francis Crick Institute, London, United Kingdom
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