Cell biology

Pinpoint regions of interest easily

Cancer research is an important field of research which investigates the causes of cancer and develops methods for treatment. The development and spread of cancer is a dynamic process which starts within the genes of a cell or a group of cells.

Download application note
What we can help you to achieve
  • Identify the region of interest rapidly

  • Understand how the cell operates within the context of surrounding tissue

  • Collect highly detailed data in vivo easily and save time with automated image overlay
cell-biology-correlative-microscopy-2_RES_feature

Study the complex relation between form and function

The SECOM platform is a unique integrated solution for correlative light and electron microscopy that enables you to do correlative microscopy extremely fast with the highest optical quality and overlay accuracy. The combination of the labeling power of fluorescence imaging and the high resolution structural information of electron microscopy makes correlative microscopy the perfect tool to study the complex relation between form and function in biology.

The SECOM platform is a unique integrated solution for correlative light and electron microscopy that enables you to do correlative microscopy extremely fast with the highest optical quality and overlay accuracy. The combination of the labeling power of fluorescence imaging and the high resolution structural information of electron microscopy makes correlative microscopy the perfect tool to study the complex relation between form and function in biology.

What can you achieve with integrated CLEM?

The integrated CLEM solution allows you to image the cell(s) of interest with both EM and FM in one integrated system, streamlining the workflow and avoiding sample damage and contamination. HeLa cells transfected with GFP-C1 have been imaged to achieve super-resolution molecular localisations of ~ 85 nm, enabling the high-precision correlation of fluorophore-labelled macromolecules to cellular ultrastructure.

Fig3aSR_Resize Fig3aWF_Resize
Superresolution image of a cell reconstructed from a sequence of approximately 30,000 images, demonstrating the improvement in the precision of YFP-A3 localisation with respect to wide field images

Use the right products to get the right results

Delmic CLEM solutions consist of powerful integrated correlative light and electron microscopy systems, which can help you understand more about your biological sample.

Talk to an expert
CLEM solutions

Talk to an expert

Get in touch with one of our experts to get more information.
Call +31 (0)15 744 01 58 or book a meeting in their agenda.

Book a meeting
Talk to Delmic expert