rapidly images cells over a large field of view using FM, to identify the area of interest based on cellular function, followed by selective high-resolution EM imaging at that location. In this way, both functional and structural data is acquired in a seamless manner.
A second solution, Fast EM, harnesses the increased throughput of a multibeam scanning EM to rapidly visualize large regions, at nanoscale resolution. High-throughput imaging enables comparative studies, where multiple samples need to be imaged and compared between healthy and diseased conditions. Fast EM also enables a bias-free method of recording data: samples are imaged in their entirety, rather than specific parts relevant only to the research question.